非那雄胺治疗雄激素性脱发在日本5年临床研

非那雄胺治疗雄激素性脱发在日本5年临床研究

研究目的

非那雄胺是雄激素性脱发的标准治疗方案，但亚洲（日本）患者的长期治疗研究有限，本研究旨在评估非那雄胺治疗雄激素性脱发的长期(5年)疗效。

研究人群

例雄激素性脱发患者

轻~重度头顶脱发(依改良Norwood/Hamilton分类为I/II/III/IV/V/VI/VII/Diffuse级)

治疗药物

非那雄胺（1mg/d）

研究时间

5年

研究终点

治疗前后患者的整体照片评分（MGPA）

研究设计如下

整体照片评分:非那雄胺治疗5年，99.4%的患者脱发改善,%的患者无继续脱发

非那雄胺长期疗效的影响因素

非那雄胺用于雄激素性秃发患者的年龄、脱发严重程度对疗效的影响

非那雄胺治疗男性型脱发—新5年研究

附录：相关文献

Five-yearefficacyoffinasterideinJapanesemenwithandrogeneticalopecia

ToshihiroYOSHITAKE,1,2,3AkiraTAKEDA,2,3KensakuOHKI,3YukoINOUE,3TakanoriYAMAWAKI,3SaoriOTSUKA,1MinekatsuAKIMOTO,2MitsuruNEMOTO,2YasuhitoSHIMAKURA,2AkioSATO1,3

Departmentsof1RegenerativePlasticSurgery,and2PlasticandAestheticSurgery,KitasatoUniversitySchoolofMedicine,Kanagawa,and3TokyoMemorialClinicHirayama,Tokyo,Japan

ABSTRACT

Finasterideisstandardmedicaltreatmentforandrogeneticalopecia;however,nolargestudieswith5yearsormoreoffollowuphavebeenperformedinJapan.TheauthorsfollowedJapanesemenwithandrogeneticalopeciatreatedwithfinasteridefor5yearstoevaluatelong-termtreatmentefficacy.Ofmentreatedwithfinasteride(1mg/day),patientswereevaluatedover5yearsbymodifiedglobalphotographicassessment.Althoughtheproportionofimprovementwashigh(99.4%),modifiedglobalphotographicassessmentscoresafter5yearsoftreatmentwerelowerinpatientswithmoreadvanceddiseaseasmeasuredbythemodifiedNorwood–Hamiltonscale.Afterseparatingpatientsinto“sufficient”and“insufficient”efficacygroupsaccordingtothemodifiedglo-balphotographicassessmentscoreafter5years(scores≥6and6,respectively),multivariateanalysisshowedthatindependentriskfactorsofinsufficientefficacywereageatstartoftreatmentof40yearsormore(P=0.)andclassificationonthemodifiedNorwood–Hamiltonscale(P0.),whereaspresenceofstressatstartoftreatmentwasanegativepredictor(P=0.).Inconclusion,continuousfinasteridetreatmentfor5yearsimprovedandrogeneticalopeciawithsustainedeffectamongJapanese.Youngerageandlessadvanceddiseaseatstartoftreatmentwerethekeypredictorsofhigherfinasterideefficacy.

Keywords:androgeneticalopecia,finasteride,Japanese,modifiedglobalphotographicassessment,modifiedNorwood–Hamiltonscale.

文献出处：YoshitakeT,etal.JournalofDermatology.;42(7):-8.

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